Associated Genetic Biomarkers
ERBB2 D769Y is present in 0.06% of AACR GENIE cases, with breast carcinoma, colorectal adenocarcinoma, non-small cell lung carcinoma, esophageal cancer, and ovarian neoplasm having the greatest prevalence .
ERBB2 D769Y is a predictive biomarker for use of trastuzumab emtansine in patients.
There are 1 NCCN guidelines that support the use of a targeted therapy based on the presence of ERBB2 D769Y.
Non-small cell lung carcinoma has the most therapies targeted against ERBB2 D769Y or its related pathways .
Trastuzumab Emtansine +
Non-Small Cell Lung Carcinoma -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Metastatic (NCCN)|
|Note: Emerging Targeted Agent for patients with HER2 mutations, per NCCN.|
Significance of ERBB2 D769Y in Diseases
Non-Small Cell Lung Carcinoma +
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