Diseases /
Malignant Peripheral Nerve Sheath Tumor
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Associated Genetic Biomarkers
Overview
NCI Definition: An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life. It usually occurs in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region. It may be associated with neurofibromatosis 1 (NF1). [1]
Malignant peripheral nerve sheath tumors most frequently harbor alterations in CDKN2A, CDKN2B, NF1, SUZ12, and TP53 [2].
CDKN2A Loss, CDKN2B Loss, NF1 Mutation, NF1 Nonsense, and NF1fs are the most common alterations in malignant peripheral nerve sheath tumor [2].
Clinical Trials
Significant Genes in Malignant Peripheral Nerve Sheath Tumor
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.