Associated Genetic Biomarkers
ERBB2 G776V is present in 0.02% of AACR GENIE cases, with colorectal adenocarcinoma, ampulla of vater carcinoma, appendiceal mucinous adenocarcinoma, bladder carcinoma, and breast carcinoma having the greatest prevalence .
ERBB2 G776V serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 G776V as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ERBB2 G776V in the inclusion eligibility criteria most commonly target breast carcinoma .
Neratinib is the most frequent therapy in trials with ERBB2 G776V as an inclusion criteria .
Significance of ERBB2 G776V in Diseases
Breast Carcinoma +
ERBB2 is mutated in 14.05% of breast carcinoma patients with ERBB2 G776V present in 0.01% of all breast carcinoma patients .
ERBB2 G776V is an inclusion criterion in 1 clinical trial for breast carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ERBB2 G776V and breast carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
Neratinib is the most frequent therapy in trials for breast carcinoma that contain ERBB2 G776V .
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