Overview

Gene Location [1]
12q13.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Variant Type
Overexpression

Significance of ERBB3 Overexpression in Diseases

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Bronchioloalveolar Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Lung Carcinoma +

Malignant Central Nervous System Neoplasm +

Malignant Solid Tumor +

Malignant Uterine Corpus Neoplasm +

Malignant Uterine Neoplasm +

Melanoma +

Multiple Myeloma +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Primary Peritoneal Carcinoma +

Prostate Carcinoma +

Soft Tissue Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20171026. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.