Gene Location [1]
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type

FGFR2 Amplification is present in 0.37% of AACR GENIE cases, with breast invasive ductal carcinoma, esophageal adenocarcinoma, gastric adenocarcinoma, adenocarcinoma of the gastroesophageal junction, and invasive breast carcinoma having the greatest prevalence [4].

Top Disease Cases with FGFR2 Amplification

Significance of FGFR2 Amplification in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Gastric Carcinoma +

Breast Carcinoma +

Cholangiocarcinoma +

Gastric Adenocarcinoma +

Cancer +

Squamous Cell Lung Carcinoma +

Endometrial Carcinoma +

Esophageal Carcinoma +

Intrahepatic Cholangiocarcinoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

Gastrointestinal Stromal Tumor +

Multiple Myeloma +

Malignant Laryngeal Neoplasm +

Invasive Breast Carcinoma +

Cervical Carcinoma +

Anaplastic Astrocytoma +

Ovarian Carcinoma +

Gallbladder Carcinoma +

Transitional Cell Carcinoma +

Bile Duct Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Malignant Uterine Neoplasm +

Pancreatic Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Glioma +

Head And Neck Carcinoma +

Melanoma +

Lung Carcinoma +

Anaplastic Oligodendroglioma +

Bronchogenic Carcinoma +

Esophageal Squamous Cell Carcinoma +

Extrahepatic Cholangiocarcinoma +

Glioblastoma +

Histiocytic And Dendritic Cell Neoplasm +

Lip And Oral Cavity Carcinoma +

Lymphocytic Neoplasm +

Malignant Salivary Gland Neoplasm +

Myeloid Neoplasm +

Myeloproliferative Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Non-Hodgkin Lymphoma +

Oropharyngeal Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.