Overview

Gene Location [1]
13q12.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Variant Type
Substitution - Missense
Gene
FLT3

FLT3 Codon 835 Missense is present in 0.36% of AACR GENIE cases, with acute myeloid leukemia, acute myeloid leukemia with myelodysplasia-related changes, acute myeloid leukemia with mutated NPM1, acute monoblastic and monocytic leukemia, and acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 having the greatest prevalence [4].

Top Disease Cases with FLT3 Codon 835 Missense

Biomarker-Directed Therapies

Significance of FLT3 Codon 835 Missense in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Acute Promyelocytic Leukemia +

Acute Leukemia +

Secondary Acute Myeloid Leukemia +

Chronic Myeloid Leukemia +

Myelodysplastic/Myeloproliferative Neoplasm +

Acute Biphenotypic Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Mediastinal Large B-Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.