Diseases /
Chronic Myelomonocytic Leukemia
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Associated Genetic Biomarkers
Overview
NCI Definition: A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement. [1]
Chronic myelomonocytic leukemias most frequently harbor alterations in TET2, SRSF2, ASXL1, NRAS, and CBL [2].
SRSF2 Mutation, SRSF2 Exon 1 Mutation, TET2 Mutation, SRSF2 Codon 95 Missense, and ASXL1fs are the most common alterations in chronic myelomonocytic leukemia [2].
Clinical Trials
Significant Genes in Chronic Myelomonocytic Leukemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.