Overview

Gene Location [1]
5q35.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Gene
FLT4

FLT4 Mutation is present in 2.58% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, endometrial endometrioid adenocarcinoma, and melanoma having the greatest prevalence [4].

Top Disease Cases with FLT4 Mutation

Significance of FLT4 Mutation in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Carcinoma +

Melanoma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Esophageal Squamous Cell Carcinoma +

Malignant Uterine Neoplasm +

Colorectal Carcinoma +

Lung Carcinoma +

Malignant Laryngeal Neoplasm +

Esophageal Carcinoma +

Multiple Myeloma +

Cancer +

Head And Neck Carcinoma +

Oropharyngeal Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Lip And Oral Cavity Carcinoma +

Nasopharyngeal Carcinoma +

Cervical Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Bile Duct Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Soft Tissue Sarcoma +

Malignant Salivary Gland Neoplasm +

Gallbladder Carcinoma +

Prostate Carcinoma +

Gastrointestinal Stromal Tumor +

Bronchogenic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.