Associated Genetic Biomarkers
IDH2 R140W is a predictive biomarker for use of enasidenib in patients.
Of the therapies with IDH2 R140W as a predictive biomarker, 1 is FDA-approved and 1 has NCCN guidelines in at least one clinical setting.
Acute myeloid leukemia has the most therapies targeted against IDH2 R140W or its related pathways .
Acute Myeloid Leukemia -
|Biomarker Criteria:||Predicted Response: Primary Sensitivity|
|Clinical Setting(s): Refractory (FDA, NCCN), Relapse (FDA, NCCN)|
|Note: Enasidenib is an IDH2 inhibitor approved by the FDA for treatment of adult patients with relapsed or refractory AML with an IDH2 mutation.|
IDH2 R140W serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain IDH2 R140W as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).
Trials with IDH2 R140W in the inclusion eligibility criteria most commonly target glioblastoma, acute myeloid leukemia, glioblastoma, IDH-wildtype, anaplastic astrocytoma, and cholangiocarcinoma .
Radiation therapy, pembrolizumab, temozolomide, idh2 inhibitor ag-221, and vbi-1901 are the most frequent therapies in trials with IDH2 R140W as an inclusion criteria .
Significance of IDH2 R140W in Diseases
Acute Myeloid Leukemia +
IDH2 is altered in 10.5% of acute myeloid leukemia patients .
IDH2 R140W is an inclusion criterion in 1 clinical trial for acute myeloid leukemia, of which 1 is open and 0 are closed. Of the trial that contains IDH2 R140W and acute myeloid leukemia as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
Enasidenib has evidence of efficacy in patients with IDH2 R140W in acute myeloid leukemia .
Malignant Solid Tumor +
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