Variant Type

IGH-CCND1 Fusion is present in 0.15% of AACR GENIE cases, with mantle cell lymphoma, multiple myeloma, endometrial endometrioid adenocarcinoma, follicular lymphoma, and mature B-cell neoplasm having the greatest prevalence [4].

Top Disease Cases with IGH-CCND1 Fusion

Significance of IGH-CCND1 Fusion in Diseases

Mantle Cell Lymphoma +

Multiple Myeloma +

Follicular Lymphoma +

Diffuse Large B-Cell Lymphoma +

Chronic Lymphocytic Leukemia +

Marginal Zone Lymphoma +

Small Lymphocytic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Grade 3b Follicular Lymphoma +

Lymphoplasmacytic Lymphoma +

Transformed Non-Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Plasma Cell Leukemia +

Primary Central Nervous System Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

Waldenstrom Macroglobulinemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.