Gene Location [1]
Receptor tyrosine kinase/growth factor signaling
Variant Type

MET Fusion is present in 0.13% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, esophageal adenocarcinoma, poorly differentiated carcinoma, NOS, and adenocarcinoma of unknown primary having the greatest prevalence [4].

Top Disease Cases with MET Fusion

Significance of MET Fusion in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Hepatocellular Carcinoma +

Cancer +

Melanoma +

Head And Neck Squamous Cell Carcinoma +

Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Glioblastoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Lymphoma +

Prostate Carcinoma +

Bladder Carcinoma +

Ewing Sarcoma +

Gastric Carcinoma +

Head And Neck Carcinoma +

Osteosarcoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

Anaplastic Astrocytoma +

Glioma +

Myelodysplastic Syndromes +

Thyroid Gland Carcinoma +

Cholangiocarcinoma +

B-Cell Non-Hodgkin Lymphoma +

Myeloid Neoplasm +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Hematologic And Lymphocytic Disorder +

Adenocarcinoma Of The Gastroesophageal Junction +

Adrenal Cortex Carcinoma +

Aggressive Systemic Mastocytosis +

Alveolar Soft Part Sarcoma +

Cervical Squamous Cell Carcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Clear Cell Sarcoma Of Soft Tissue +

Desmoid-Type Fibromatosis +

Diffuse Intrinsic Pontine Glioma +

Gastric Adenocarcinoma +

Gliosarcoma +

Hepatoblastoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Medulloblastoma +

Mesothelioma +

Multiple Myeloma +

Oropharyngeal Squamous Cell Carcinoma +

Pecoma +

Pancreatic Adenocarcinoma +

Papillary Renal Cell Carcinoma +

Peritoneal Mesothelioma +

Rhabdomyosarcoma +

Sarcoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thyroid Gland Medullary Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Wilms Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.