Gene Location [1]
Receptor tyrosine kinase/growth factor signaling

MET Mutation is present in 1.90% of AACR GENIE cases, with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, melanoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence [4].

Top Disease Cases with MET Mutation

Significance of MET Mutation in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Cancer +

Colorectal Carcinoma +

Breast Carcinoma +

Hepatocellular Carcinoma +

Glioblastoma +

Bladder Carcinoma +

Head And Neck Carcinoma +

Prostate Carcinoma +

Endometrial Carcinoma +

Renal Cell Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Ovarian Carcinoma +

Lymphoma +

Soft Tissue Sarcoma +

Pancreatic Carcinoma +

Papillary Renal Cell Carcinoma +

Malignant Uterine Neoplasm +

Lung Carcinoma +

Urothelial Carcinoma +

Cervical Squamous Cell Carcinoma +

Glioma +

Cervical Carcinoma +

Anaplastic Astrocytoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gliosarcoma +

Esophageal Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Medulloblastoma +

Ewing Sarcoma +

Mesothelioma +

Sarcoma +

Multiple Myeloma +

Pancreatic Adenocarcinoma +

Gallbladder Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Osteosarcoma +

Thyroid Gland Medullary Carcinoma +

Adrenal Cortex Carcinoma +

Bile Duct Carcinoma +

Cholangiocarcinoma +

Rhabdomyosarcoma +

Alveolar Soft Part Sarcoma +

Bronchogenic Carcinoma +

Clear Cell Sarcoma Of Soft Tissue +

Diffuse Intrinsic Pontine Glioma +

Hepatoblastoma +

Mucosal Melanoma +

Wilms Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.