Associated Genetic Biomarkers
NTRK1 A608D is a predictive biomarker for use of larotrectinib in patients.
Of the therapies with NTRK1 A608D as a predictive biomarker, 1 is FDA-approved in at least one clinical setting.
Malignant solid tumor has the most therapies targeted against NTRK1 A608D or its related pathways .
Malignant Solid Tumor -
|Biomarker Criteria:||Predicted Response: Acquired Resistance|
|Clinical Setting(s): Metastatic (FDA, MCG)|
|Note: Secondary mutations in the NTRK genes confer resistance to larotrectinib.|
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