Biomarkers /
NTRK1
Overview
NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) encodes the high affinity nerve growth factor receptor protein. NTRK1 fusions have been observed in colorectal cancer (PMID: 2869410), papillary thyroid cancer (PMID: 19883730), lung cancer (PMID: 24162815), glioblastoma (PMID: 19883730; PMID: 24647444), and cholangiocarcinoma (PMID: 24563076). NTRK1 fusions trigger constitutive TRKA kinase activity (PMID: 24162815), which activates cell growth and differentiation pathways (PMID: 12652644).
Biomarker-Directed Therapies
Clinical Trials
Significance of NTRK1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.

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