Overview

Variant Type
Expression

Significance of PD-L1 Expression (CPS >= 1) in Diseases

Head And Neck Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Adenocarcinoma +

Malignant Solid Tumor +

Oropharyngeal Squamous Cell Carcinoma +

Hypopharyngeal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Non-Small Cell Lung Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Melanoma +

Urothelial Carcinoma +

Cervical Carcinoma +

Pancreatic Adenocarcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Merkel Cell Carcinoma +

Non-Squamous Non-Small Cell Lung Carcinoma +

Renal Cell Carcinoma +

Skin Squamous Cell Carcinoma +

Small Cell Lung Carcinoma +

Basal Cell Carcinoma +

Biliary Tract Carcinoma +

Carcinoma Of Unknown Primary +

Cervical Adenocarcinoma +

Cervical Adenosquamous Carcinoma +

Cervical Squamous Cell Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Colorectal Adenocarcinoma +

Endometrial Carcinoma +

Esophageal Adenocarcinoma +

Esophageal Carcinoma +

Gallbladder Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Hodgkin Lymphoma +

Mesothelioma +

Oropharyngeal Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Pancreatic Ductal Adenocarcinoma +

Peritoneal Malignant Mesothelioma +

Pleural Biphasic Mesothelioma +

Pleural Epithelioid Mesothelioma +

Pleural Mesothelioma, Sarcomatoid Type +

Primary Mediastinal B-Cell Lymphoma +

Prostate Carcinoma +

Squamous Cell Carcinoma Of Unknown Primary +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.