Associated Genetic Biomarkers
SRC Loss is present in 0.07% of AACR GENIE cases, with high grade ovarian serous adenocarcinoma, lung adenocarcinoma, myelodysplastic syndromes, prostate adenocarcinoma, and acute myeloid leukemia having the greatest prevalence .
SRC Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains SRC Loss as an inclusion criterion, 1 is phase 2 (1 open).
Significance of SRC Loss in Diseases
Malignant Solid Tumor +
SRC is altered in 1.18% of malignant solid tumor patients with SRC Loss present in 0.03% of all malignant solid tumor patients .
SRC Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains SRC Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
B-Cell Non-Hodgkin Lymphoma +
SRC is altered in 0.09% of B-cell non-hodgkin lymphoma patients .
SRC Loss is an inclusion criterion in 1 clinical trial for B-cell non-hodgkin lymphoma, of which 1 is open and 0 are closed. Of the trial that contains SRC Loss and B-cell non-hodgkin lymphoma as inclusion criteria, 1 is phase 2 (1 open) .
Multiple Myeloma +
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.