Overview

NCI Definition: An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. (WHO, 2001) [1]

Acute megakaryoblastic leukemias most frequently harbor alterations in JAK2, DNMT3A, TP53, TET2, and PRKDC [2].

Most Commonly Altered Genes in Acute Megakaryoblastic Leukemia

JAK2 V617F, JAK2 Mutation, JAK2 Exon 14 Mutation, DNMT3A Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in acute megakaryoblastic leukemia [2].

Top Alterations in Acute Megakaryoblastic Leukemia

Significant Genes in Acute Megakaryoblastic Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NRIP3 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
Acute Megakaryoblastic Leukemia (FAB Type M7), Acute Megakaryocytic Leukemia, Acute M7 Myeloid Leukemia, FAB M7, LEUKEMIA, MEGAKARYOCYTIC, MALIGNANT
Parent(s)
Acute Myeloid Leukemia Not Otherwise Specified
OncoTree Name
Acute Megakaryoblastic Leukemia
OncoTree Code
AMKL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.