Overview

NCI Definition: An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. (WHO, 2001) [1]

Significant Genes in Acute Megakaryoblastic Leukemia

ABL1 +

AFF1 +

BCR +

CBFA2T3 +

CREBBP +

DEK +

ELL +

ETV6 +

FLT3 +

GLIS2 +

HOXA9 +

KAT6A +

KDM5A +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MNX1 +

NSD1 +

NUP214 +

NUP98 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

WT1 +

Disease Details

Synonyms
Acute M7 Myeloid Leukemia, Acute Megakaryocytic Leukemia, LEUKEMIA, MEGAKARYOCYTIC, MALIGNANT, Acute Megakaryoblastic Leukemia (FAB Type M7), FAB M7
Parent(s)
Acute Myeloid Leukemia Not Otherwise Specified
OncoTree Name
Acute Megakaryoblastic Leukemia
OncoTree Code
AMKL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.