Overview

NCI Definition: An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells. [1]

Adenosquamous lung carcinomas most frequently harbor alterations in TP53, KRAS, EGFR, PIK3CA, and CDKN2A [2].

Most Commonly Altered Genes in Adenosquamous Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in adenosquamous lung carcinoma [2].

Top Alterations in Adenosquamous Lung Carcinoma

Disease Details

Synonyms
Lung Adenosquamous Carcinoma, Adenosquamous Lung Cancer, Adenosquamous Cell Lung Carcinoma
Parent(s)
Adenosquamous Carcinoma
OncoTree Name
Lung Adenosquamous Carcinoma
OncoTree Code
LUAS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.