Overview

NCI Definition: An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells. [1]

Adenosquamous lung carcinomas most frequently harbor alterations in TP53, KRAS, EGFR, MET, and PIK3CA [2].

Most Commonly Altered Genes in Adenosquamous Lung Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in adenosquamous lung carcinoma [2].

Top Alterations in Adenosquamous Lung Carcinoma

Disease Details

Synonyms
Adenosquamous Lung Cancer, Lung Adenosquamous Carcinoma, Adenosquamous Cell Lung Carcinoma
Parent(s)
Non-Squamous Non-Small Cell Lung Carcinoma
OncoTree Name
Lung Adenosquamous Carcinoma
OncoTree Code
LUAS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.