NCI Definition: A usually aggressive large B-cell lymphoma characterized by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack the 2;5 translocation. [1]

Significant Genes in ALK-Positive Large B-Cell Lymphoma


BCL2 +

BCL6 +

IRF4 +


Disease Details

ALK-DLBCL, ALK Positive Large B-Cell Lymphoma, Diffuse Large B-Cell Lymphoma with Expression of Full-Length ALK, Diffuse Large B-Cell Lymphoma with Expression of Full-Length Anaplastic Lymphoma Kinase
Diffuse Large B-Cell Lymphoma
OncoTree Name
ALK Positive Large B-Cell Lymphoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.