Overview

NCI Definition: A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential. It may arise from a low-grade astrocytoma, but it can also be diagnosed at first biopsy, without indication of a less malignant precursor lesion. It has an intrinsic tendency for malignant progression to glioblastoma. (WHO) [1]

Significant Genes in Anaplastic Astrocytoma

ABL2 +

ACVR1B +

APC +

ASXL1 +

ATM +

ATR +

ATRX +

BLM +

BRCA1 +

BRCA2 +

CDK12 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CTDNEP1 +

CTNNB1 +

CYLD +

DDX3X +

DICER1 +

DNMT3A +

EGFR +

ERBB3 +

EZH2 +

FGF19 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA3 +

GLI2 +

H3F3A +

HGF +

IDH1 +

IDH2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2C +

KMT2D +

KRAS +

LRP1B +

MAGI2 +

MAP3K1 +

MDM4 +

MED12 +

MET +

MSH2 +

MSH6 +

MYC +

MYCL +

MYCN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

OTX2 +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PPM1D +

PTCH1 +

PTEN +

PTPN11 +

PVT1 +

RB1 +

RELA +

RUNX1 +

SETD2 +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SOX9 +

STAG2 +

SUFU +

TAF1 +

TBX3 +

TERT +

TET2 +

TP53 +

XPO1 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
Grade III Astrocytic Tumor, Malignant Astrocytoma, High-grade astrocytoma, NOS, Infiltrating glioma (anaplastic astrocytoma WHO grade III), Grade III Astrocytoma, Brain anaplastic astrocytoma, Recurrent Anaplastic Astrocytoma WHO Grade III, Anaplastic Astrocytoma WHO Grade III, ASTROCYTOMA, ANAPLASTIC, MALIGNANT, Grade III Astrocytic Neoplasm
Parent(s)
WHO Grade III Glioma
Children
Anaplastic Astrocytoma, IDH-Mutant, Childhood Anaplastic Astrocytoma, and Anaplastic Astrocytoma, IDH-Wildtype
OncoTree Name
Anaplastic Astrocytoma
OncoTree Code
AASTR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.