Overview

NCI Definition: A diffusely infiltrating, WHO grade III astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential. It may arise from a low-grade astrocytoma, but it can also be diagnosed at first biopsy, without indication of a less malignant precursor lesion. It has an intrinsic tendency for malignant progression to glioblastoma. (WHO) [1]

Anaplastic astrocytomas most frequently harbor alterations in TP53, IDH1, ATRX, EGFR, and CDKN2A [2].

Most Commonly Altered Genes in Anaplastic Astrocytoma

TP53 Mutation, IDH1 Mutation, IDH1 Codon 132 Missense, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in anaplastic astrocytoma [2].

Top Alterations in Anaplastic Astrocytoma

Significant Genes in Anaplastic Astrocytoma

ABL2 +

ACVR1B +

APC +

ASXL1 +

ATM +

ATR +

ATRX +

BLM +

BRAF +

BRCA1 +

BRCA2 +

CDK12 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CTDNEP1 +

CTNNB1 +

CYLD +

DDX3X +

DICER1 +

DNMT3A +

EGFR +

ERBB2 +

ERBB3 +

EZH2 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

GATA3 +

GLI2 +

H3F3A +

HGF +

IDH1 +

IDH2 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2C +

KMT2D +

KRAS +

LRP1B +

MAGI2 +

MAP3K1 +

MDM4 +

MED12 +

MET +

MSH2 +

MSH6 +

MYC +

MYCL +

MYCN +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

OTX2 +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PPM1D +

PTCH1 +

PTEN +

PTPN11 +

PVT1 +

RB1 +

RELA +

RUNX1 +

SETD2 +

SHH +

SMARCA4 +

SMO +

SNCAIP +

SOX9 +

STAG2 +

SUFU +

TAF1 +

TBX3 +

TERT +

TET2 +

TP53 +

XPO1 +

YAP1 +

ZMYM3 +

Disease Details

Synonyms
ASTROCYTOMA, ANAPLASTIC, MALIGNANT, Malignant Astrocytoma, Grade III Astrocytic Neoplasm, Brain anaplastic astrocytoma, High-grade astrocytoma, NOS, Grade III Astrocytoma, Grade III Astrocytic Tumor
Parent(s)
WHO Grade III Glioma
Children
Anaplastic Astrocytoma, IDH-Mutant, Childhood Anaplastic Astrocytoma, and Anaplastic Astrocytoma, IDH-Wildtype
OncoTree Name
Anaplastic Astrocytoma
OncoTree Code
AASTR

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.