Overview

NCI Definition: A T-cell peripheral lymphoma morphologically indistinguishable from anaplastic large cell lymphoma, ALK-positive. It is characterized by the absence of the translocation involving the ALK gene and lacks expression of ALK fusion protein. [1]

Anaplastic large cell lymphoma, ALK-negatives most frequently harbor alterations in STAT3, JAK1, TP53, STAG2, and SOCS1 [2].

STAT3 Mutation, JAK1 Mutation, TP53 X307_splice, STAT3 Y640F, and STAT3 S614R are the most common alterations in anaplastic large cell lymphoma, ALK-negative [2].

Significant Genes in Anaplastic Large Cell Lymphoma, ALK-Negative

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.