NCI Definition: A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement. [1]

Anaplastic large cell lymphoma, ALK-positives most frequently harbor alterations in G3BP1, ALK, SF3B1, GRIN2A, and EP400 [2].

Most Commonly Altered Genes in Anaplastic Large Cell Lymphoma, ALK-Positive

ALK-G3BP1 Fusion, ALK Fusion, SF3B1 R558K, SF3B1 Mutation, and GRIN2A R1088K are the most common alterations in anaplastic large cell lymphoma, ALK-positive [2].

Top Alterations in Anaplastic Large Cell Lymphoma, ALK-Positive

Significant Genes in Anaplastic Large Cell Lymphoma, ALK-Positive


BCL2 +

BCL6 +


Disease Details

ALK-Positive Anaplastic Large Cell Lymphoma, Anaplastic Large Cell Lymphoma ALK Positive, ALKoma, ALCL, ALK+
Anaplastic Large Cell Lymphoma
OncoTree Name
Anaplastic Large-Cell Lymphoma ALK Positive
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.