Overview

NCI Definition: A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement. [1]

Significant Genes in Anaplastic Large Cell Lymphoma, ALK-Positive

ALK +

Disease Details

Synonyms
ALK-Positive Anaplastic Large Cell Lymphoma, ALCL, ALK+, ALKoma, Anaplastic Large Cell Lymphoma ALK Positive
Parent(s)
Anaplastic Large Cell Lymphoma
OncoTree Name
Anaplastic Large Cell Lymphoma ALK Positive
OncoTree Code
ALCLALKP

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.