Diseases /
Angioimmunoblastic T-Cell Lymphoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A mature T-cell non-Hodgkin lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes and extranodal sites. The clinical course is typically aggressive. [1]
Angioimmunoblastic T-cell lymphomas most frequently harbor alterations in TET2, RHOA, DNMT3A, IDH2, and VAV1 [2].
TET2 Mutation, TET2fs, RHOA Mutation, RHOA G17V, and TET2 Nonsense are the most common alterations in angioimmunoblastic T-cell lymphoma [2].
Clinical Trials
Significant Genes in Angioimmunoblastic T-Cell Lymphoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.