NCI Definition: The most common histologic type of breast carcinoma. Representative examples include invasive ductal carcinoma not otherwise specified, ductal carcinoma in situ, inflammatory carcinoma, secretory carcinoma, signet ring cell carcinoma, tubular carcinoma, invasive lobular carcinoma, and lobular carcinoma in situ. [1]

Breast adenocarcinomas most frequently harbor alterations in TP53, PIK3CA, ERBB2, GATA3, and CDH1 [2].

Most Commonly Altered Genes in Breast Adenocarcinoma

PIK3CA Mutation, TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and PIK3CA Codon 1047 Missense are the most common alterations in breast adenocarcinoma [2].

Top Alterations in Breast Adenocarcinoma

Significant Genes in Breast Adenocarcinoma

AKT1 +




ESR1 +




Disease Details

Adenocarcinoma of Breast, Adenocarcinoma of the Breast, Metastatic adenocarcinoma, c/w breast primary, Mammary adenocarcinoma
Breast Carcinoma
Invasive Breast Cribriform Carcinoma, Oncocytic Breast Carcinoma, Breast Ductal Carcinoma, Breast Adenocarcinoma with Spindle Cell Metaplasia, Inflammatory Breast Carcinoma, Lobular Breast Carcinoma, Glycogen-Rich Carcinoma, Paget Disease of the Breast, Signet Ring Cell Breast Carcinoma, and Mixed Lobular and Ductal Breast Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.