Associated Genetic Biomarkers

Overview

NCI Definition: The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001) [1]

Chronic lymphocytic leukemias most frequently harbor alterations in TP53, NOTCH1, ATM, SF3B1, and KMT2D [2].

Most Commonly Altered Genes in Chronic Lymphocytic Leukemia

TP53 Mutation, NOTCH1 Mutation, ATM Mutation (germline), ATM Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in chronic lymphocytic leukemia [2].

Top Alterations in Chronic Lymphocytic Leukemia

Significant Genes in Chronic Lymphocytic Leukemia

ABL1 +

AFF1 +

ATM +

BCL2 +

BCL6 +

BCR +

BIRC3 +

BRAF +

BTK +

CBFB +

CCND1 +

DEK +

ELL +

ERBB2 +

FGFR3 +

FLT3 +

IGH +

KIT +

KMT2A +

MAF +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

MYH11 +

NOTCH1 +

NPM1 +

NUP214 +

PBX1 +

PLCG2 +

PML +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

TCF3 +

TP53 +

WHSC1 +

Disease Details

Synonyms
Hematopoeitic - Chronic Lymphocytic Leukemia (CLL), B Cell Lymphocytic Leukemia, B Cell Chronic Lymphocytic Leukemia, B-Cell Chronic Lymphocytic Leukemia, B-Cell Chronic Lymphogenous Leukemia, Chronic B-Cell Lymphocytic Leukemia, Chronic Lymphogenous Leukemia, Chronic lymphocytic leukemia, NOS, B-Cell Lymphocytic Leukemia, B Cell CLL, Chronic Lymphocytic Leukemia (CLL), B-Cell Chronic Lymphoid Leukemia, Chronic Lymphatic Leukemia, CLL, B-Cell CLL, BCLL
Parent(s)
Lymphoid Leukemia
Children
Richter Syndrome
OncoTree Name
Chronic Lymphocytic Leukemia
OncoTree Code
CLL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.