Associated Genetic Biomarkers

Overview

NCI Definition: The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001) [1]

Significant Genes in Chronic Lymphocytic Leukemia

ABL1 +

AFF1 +

ASXL1 +

ATM +

BCL2 +

BCL6 +

BCR +

BIRC3 +

BRAF +

BTK +

CBFB +

CCND1 +

DEK +

ELL +

FGFR3 +

FLT3 +

IGH +

IRAK1 +

JAK2 +

JAK3 +

KIT +

KMT2A +

MAF +

MAFB +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

MYD88 +

MYH11 +

NOTCH1 +

NPM1 +

NRIP3 +

NUP214 +

PBX1 +

PLCG2 +

PML +

RARA +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

TCF3 +

TP53 +

TYK2 +

WHSC1 +

Disease Details

Synonyms
B Cell CLL, Chronic Lymphocytic Leukemia (CLL), CLL, Chronic Lymphogenous Leukemia, BCLL, B-Cell CLL, B Cell Lymphocytic Leukemia, B-Cell Chronic Lymphocytic Leukemia, Hematopoeitic - Chronic Lymphocytic Leukemia (CLL), Bone marrow leukemia lymphocytic chronic (CLL), Chronic B-Cell Lymphocytic Leukemia, B-Cell Lymphocytic Leukemia, Chronic lymphocytic leukemia, NOS, B-Cell Chronic Lymphoid Leukemia, B Cell Chronic Lymphocytic Leukemia, Chronic Lymphatic Leukemia, B-Cell Chronic Lymphogenous Leukemia
Parent(s)
Lymphoid Leukemia
Children
Richter Syndrome

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.