NCI Definition: A chronic myelomonocytic leukemia characterized by the presence of less than 10 percent blasts in the bone marrow and less than 5 percent blasts in the peripheral blood. [1]

Chronic myelomonocytic leukemia-1s most frequently harbor alterations in TET2, SRSF2, ASXL1, CBL, and NRAS [2].

Most Commonly Altered Genes in Chronic Myelomonocytic Leukemia-1

TET2 Mutation, SRSF2 Mutation, SRSF2 Exon 1 Mutation, SRSF2 Codon 95 Missense, and TET2 Nonsense are the most common alterations in chronic myelomonocytic leukemia-1 [2].

Top Alterations in Chronic Myelomonocytic Leukemia-1

Significant Genes in Chronic Myelomonocytic Leukemia-1


MLF1 +

NPM1 +

RPN1 +

Disease Details

Chronic Myelomonocytic Leukemia
OncoTree Name
Chronic Myelomonocytic Leukemia-1
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.