Biomarkers /
MLF1
Overview
Myeloid leukemia factor 1 (MLF1) is a gene that encodes a protein that functions in the phenotypic determination of hemopoietic cells. Fusions and nonsense mutations are observed in cancers such as intestinal cancer.
MLF1 is altered in 0.12% of all cancers with high grade ovarian serous adenocarcinoma, appendix signet ring cell carcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, and endometrial serous adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in MLF1 are MLF1 V98M (0.28%), MLF1 G260C (0.22%), MLF1 H245Q (0.39%), MLF1 R131C (0.39%), and MLF1 R27* (3.85%) [3].
Clinical Trials
Significance of MLF1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.