Overview

NCI Definition: A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network. The tumor may metastasize to unusual sites and late metastasis is common. [1]

Significant Genes in Clear Cell Renal Cell Carcinoma

ATM +

ATR +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FH +

IDH1 +

IDH2 +

KRAS +

MCPH1 +

MET +

MRE11A +

MYC +

NBN +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RB1 +

SDHA +

SDHB +

SDHC +

SDHD +

SETD2 +

SLX4 +

TP53 +

Disease Details

Synonyms
RCC, clear cell adenocarcinoma, Conventional (Clear Cell) Renal Cell Adenocarcinoma, Hypernephroma, Clear Cell Adenocarcinoma, Kidney, Clear Cell Carcinoma of Kidney, Clear Cell Adenocarcinoma of Kidney, Conventional (Clear Cell) Renal Cell Carcinoma, Kidney Clear Cell Carcinoma, Clear Cell Carcinoma of the Kidney, Conventional Renal Cell Carcinoma, Kidney Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma of the Kidney, Renal Clear Cell Carcinoma, Renal Clear Cell Adenocarcinoma, Renal cell carcinoma, clear cell adenocarcinoma, Grawitz Tumor
Parent(s)
Renal Cell Carcinoma
Children
Renal Clear Cell Carcinoma with Sarcomatoid Features and Clear Cell Papillary Renal Cell Carcinoma
OncoTree Name
Renal Clear Cell Carcinoma
OncoTree Code
CCRCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.