Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
11p14.3
Pathway
DNA damage/repair
Protein [2]
Fanconi anemia group F protein
Synonyms [1]
FAF

Fanconi anemia, complementation group F (FANCF) is a gene that encodes a protein that is a member of the Fanconi anemia complementation group. The protein complex functions in the heterogeneous recessive disorder Fanconi anemia that causes cytogenetic instability, hypersensitivity to DNA crosslinking agents, increases chromosomal breakage, and defective DNA repair. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

FANCF is altered in 1.01% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

FANCF GENIE Cases - Top Diseases

The most common alterations in FANCF are FANCF Mutation (0.97%), FANCF Nonsense (0.08%), FANCF Frameshift (0.06%), FANCF R216P (0.08%), and FANCF L162fs (0.04%) [3].

FANCF GENIE Cases - Top Alterations

Significance of FANCF in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Primary Peritoneal Carcinoma +

Fallopian Tube Carcinoma +

Small Cell Lung Carcinoma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Adenocarcinoma +

Endometrial Carcinoma +

Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Soft Tissue Sarcoma +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Esophageal Carcinoma +

Head And Neck Carcinoma +

Squamous Cell Lung Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Gastrointestinal Stromal Tumor +

Osteosarcoma +

Mantle Cell Lymphoma +

Leiomyosarcoma +

Ampulla Of Vater Carcinoma +

Bladder Urothelial Carcinoma +

Clear Cell Renal Cell Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Colorectal Adenocarcinoma +

Malignant Intestinal Neoplasm +

B-Cell Non-Hodgkin Lymphoma +

Gastric Adenocarcinoma +

Malignant Gastric Neoplasm +

Invasive Breast Carcinoma +

Malignant Small Intestinal Neoplasm +

Neuroblastoma +

Malignant Mesothelioma +

Low Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Cancer +

Malignant Ovarian Epithelial Tumor +

Multiple Myeloma +

Esophageal Adenocarcinoma +

Glioma +

Malignant Central Nervous System Neoplasm +

Bile Duct Adenocarcinoma +

Cholangiocarcinoma +

Diffuse Large B-Cell Lymphoma +

Melanoma +

Biliary Tract Carcinoma +

Anal Carcinoma +

Ewing Sarcoma +

Medulloblastoma +

Ovarian Clear Cell Adenocarcinoma +

Pancreatic Ductal Adenocarcinoma +

Penile Carcinoma +

Rhabdomyosarcoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.