Overview

NCI Definition: An adenocarcinoma arising from the colon. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, colonic adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [1]

Colon adenocarcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Colon Adenocarcinoma

APC Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, and TP53 c.1-c.137 Missense are the most common alterations in colon adenocarcinoma [2].

Top Alterations in Colon Adenocarcinoma

Significant Genes in Colon Adenocarcinoma

MLH1 +

MSH2 +

MSH6 +

PIK3CA +

PMS2 +

POLE +

Disease Details

Synonyms
Adenocarcinoma - colon, Adenocarcinoma of Colon, Adenocarcinoma of the Colon, Colonic Adenocarcinoma
Parent(s)
Colon Carcinoma
Children
Submucosal Invasive Colon Adenocarcinoma, Colon Signet Ring Cell Adenocarcinoma, Colon Mucinous Adenocarcinoma, Cecum Adenocarcinoma, Colon Adenocarcinoma In Situ, and Colon Medullary Carcinoma
OncoTree Name
Colon Adenocarcinoma
OncoTree Code
COAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.