Overview

NCI Definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [1]

Colon carcinomas most frequently harbor alterations in APC, TP53, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Colon Carcinoma

APC Mutation, TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in colon carcinoma [2].

Top Alterations in Colon Carcinoma

Significant Genes in Colon Carcinoma

APH1A +

BRAF +

DLL4 +

ERBB2 +

FBXW7 +

JAG1 +

KRAS +

MAML1 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NCSTN +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NRAS +

PMS1 +

PMS2 +

WNT5A +

Disease Details

Synonyms
Colon Cancer, Colonic Carcinoma, Carcinoma of Colon, Carcinoma of the Colon
Parent(s)
Malignant Colon Neoplasm
Children
Stage 0 Colon Cancer, Colon Small Cell Neuroendocrine Carcinoma, Colon Adenosquamous Carcinoma, Colon Adenocarcinoma, Colon Squamous Cell Carcinoma, and Cecum Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.