Overview

NCI Definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [1]

Colon carcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Colon Carcinoma

APC Mutation, TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in colon carcinoma [2].

Top Alterations in Colon Carcinoma

Significant Genes in Colon Carcinoma

APH1A +

BRAF +

DLL4 +

ERBB2 +

FBXW7 +

JAG1 +

KRAS +

MAML1 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NCSTN +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NRAS +

PIK3CA +

PIK3R1 +

PMS1 +

PMS2 +

PTEN +

WNT5A +

Disease Details

Synonyms
Colonic Carcinoma, Carcinoma of the Colon, Carcinoma of Colon, Colon Cancer
Parent(s)
Malignant Colon Neoplasm
Children
Colon Small Cell Neuroendocrine Carcinoma, Colon Squamous Cell Carcinoma, Colon Large Cell Neuroendocrine Carcinoma, Colon Adenosquamous Carcinoma, Stage 0 Colon Cancer, Cecum Carcinoma, and Colon Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.