Overview

NCI Definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [1]

Significant Genes in Colon Carcinoma

APH1A +

BRAF +

DLL4 +

FBXW7 +

JAG1 +

KRAS +

MAML1 +

NCSTN +

NOTCH1 +

NOTCH2 +

NOTCH3 +

NOTCH4 +

NRAS +

PIK3CA +

PIK3R1 +

PTEN +

WNT5A +

Disease Details

Synonyms
Colon Cancer, Carcinoma of Colon, Carcinoma of the Colon, Colonic Carcinoma
Parent(s)
Malignant Colon Neoplasm
Children
Cecum Carcinoma, Colon Small Cell Neuroendocrine Carcinoma, Colon Adenocarcinoma, Colon Squamous Cell Carcinoma, Colon Large Cell Neuroendocrine Carcinoma, Colon Adenosquamous Carcinoma, and Stage 0 Colon Cancer

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.