Associated Genetic Biomarkers

Overview

NCI Definition: The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [1]

Colorectal adenocarcinomas most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Colorectal Adenocarcinoma

APC Mutation, TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in colorectal adenocarcinoma [2].

Top Alterations in Colorectal Adenocarcinoma

Significant Genes in Colorectal Adenocarcinoma

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CHEK1 +

CHEK2 +

DPYD +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HRAS +

KRAS +

MCPH1 +

MET +

MLH1 +

MLH3 +

MRE11A +

MSH2 +

MSH3 +

MSH6 +

NBN +

NRAS +

PALB2 +

PMS1 +

PMS2 +

POLE +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

SLX4 +

TP53 +

Disease Details

Synonyms
Large Intestine Adenocarcinoma, Adenocarcinoma of Large Intestine, Adenocarcinoma of Large Bowel, Adenocarcinoma of the Large Bowel, Large Bowel Adenocarcinoma, Adenocarcinoma of the Large Intestine
Parent(s)
Adenocarcinoma
Children
Rectal Adenocarcinoma, Colon Adenocarcinoma, Colorectal Mucinous Adenocarcinoma, Colorectal Signet Ring Cell Carcinoma, and Rectosigmoid Adenocarcinoma
OncoTree Name
Colorectal Adenocarcinoma
OncoTree Code
COADREAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.