Associated Genetic Biomarkers

Overview

NCI Definition: The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [1]

Significant Genes in Colorectal Adenocarcinoma

ATM +

ATR +

BARD1 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

DPYD +

EGFR +

ERBB2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HRAS +

KRAS +

MCPH1 +

MET +

MRE11A +

NBN +

NRAS +

PALB2 +

POLE +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

SLX4 +

TP53 +

UGT1A1 +

Disease Details

Synonyms
Large Intestine Adenocarcinoma, Adenocarcinoma c/w Colorectal Primary, Adenocarcinoma of the Large Intestine, Adenocarcinoma of the Large Bowel, Adenocarcinoma of Large Bowel, Adenocarcinoma of Large Intestine, Metastatic adenocarcinoma, c/w colorectal primary, Large Bowel Adenocarcinoma
Parent(s)
Colorectal Carcinoma
Children
Colorectal Mucinous Adenocarcinoma, Rectosigmoid Adenocarcinoma, Colon Adenocarcinoma, Colorectal Signet Ring Cell Carcinoma, and Rectal Adenocarcinoma
OncoTree Name
Colorectal Adenocarcinoma
OncoTree Code
COADREAD

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.