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Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
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Associated Genetic Biomarkers
Overview
NCI Definition: A term referring to a group of diffuse large B-cell lymphomas which are biologically heterogeneous and lack definitive and accepted criteria for further subclassification. These lymphomas have a centroblastic, immunoblastic, or anaplastic morphology. [1]
Diffuse large B-cell lymphoma, not otherwise specifieds most frequently harbor alterations in KMT2D, TP53, CREBBP, PIM1, and BCL2 [2].
CREBBP Mutation, KMT2D Mutation, TP53 Mutation, MYD88 Mutation, and PIM1 Mutation are the most common alterations in diffuse large B-cell lymphoma, not otherwise specified [2].
Significant Genes in Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.