Overview

NCI Definition: A term referring to a group of diffuse large B-cell lymphomas which are biologically heterogeneous and lack definitive and accepted criteria for further subclassification. These lymphomas have a centroblastic, immunoblastic, or anaplastic morphology. [1]

Significant Genes in Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

AFF1 +

ALK +

BCL2 +

BCL6 +

ELL +

IRF4 +

KMT2A +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

Disease Details

Synonyms
DLBCL, NOS, Diffuse Large B-Cell Lymphoma, NOS
Parent(s)
Diffuse Large B-Cell Lymphoma
Children
Diffuse Large B-Cell Lymphoma Activated B-Cell Type and Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma
OncoTree Name
Diffuse Large B-Cell Lymphoma, NOS
OncoTree Code
DLBCLNOS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.