Overview

NCI Definition: A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis. [1]

Significant Genes in Embryonal Rhabdomyosarcoma

ARAF +

BRAF +

CRKL +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MYCN +

NF1 +

NRAS +

RAF1 +

SRC +

Disease Details

Synonyms
ERMS, Soft tissue rhabdomyosarcoma embryonal
Parent(s)
Rhabdomyosarcoma
Children
Botryoid-Type Embryonal Rhabdomyosarcoma, Spindle Cell Rhabdomyosarcoma, Extrahepatic Bile Duct Embryonal Rhabdomyosarcoma, and Orbit Embryonal Rhabdomyosarcoma
OncoTree Name
Embryonal Rhabdomyosarcoma
OncoTree Code
ERMS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.