Overview

NCI Definition: A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor. [1]

Germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, CCND2, ETV6, and RAD52 [2].

Most Commonly Altered Genes in Germ Cell Tumor

CDKN1B Amplification, KRAS Amplification, CCND2 Amplification, ETV6 Amplification, and RAD52 Amplification are the most common alterations in germ cell tumor [2].

Top Alterations in Germ Cell Tumor

Significant Genes in Germ Cell Tumor

BRAF +

BRCA1 +

BRCA2 +

CCND1 +

CCND2 +

CCND3 +

CCNE1 +

CCNE2 +

CDK2 +

CDK4 +

CDK6 +

CDKN1A +

CDKN1B +

CDKN2A +

ERBB2 +

KRAS +

MYCN +

RB1 +

Disease Details

Synonyms
Tumor of Germ Cell, Neoplasm of Germ Cell, Germ Cell Neoplasm, Tumor of the Germ Cell, Neoplasm of the Germ Cell
Parent(s)
Solid Neoplasm
Children
Testicular Germ Cell Tumor, Fallopian Tube Germ Cell Tumor, Malignant Germ Cell Tumor, Mixed Germ Cell Cancer, Nongerminomatous Germ Cell Tumor, Teratoma, Extragonadal Germ Cell Tumor, Ovarian Germ Cell Tumor, and Childhood Germ Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.