Diseases /
Hairy Cell Leukemia
Back to Diseases List
Associated Genetic Biomarkers
Overview
NCI Definition: A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001) [1]
Hairy cell leukemias most frequently harbor alterations in BRAF, ATM, NF1, EP400, and DNMT3A [2].
BRAF V600E, BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, and ATM Mutation are the most common alterations in hairy cell leukemia [2].
Biomarker-Directed Therapies
Clinical Trials
Significant Genes in Hairy Cell Leukemia
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.