Overview

NCI Definition: A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001) [1]

Biomarker-Directed Therapies

Significant Genes in Hairy Cell Leukemia

BRAF +

MYC +

Disease Details

Synonyms
HCL, Hairy Cell Leukemia (HCL), Leukemic Reticuloendotheliosis
Parent(s)
Mature B-Cell Neoplasm
Children
Splenic Manifestation of Hairy Cell Leukemia and Refractory Hairy Cell Leukemia
OncoTree Name
Hairy Cell Leukemia
OncoTree Code
HCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.