Hairy Cell Leukemia

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Associated Genetic Biomarkers

Overview

NCI Definition: A neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients present with splenomegaly and pancytopenia. (WHO, 2001) [1]

Biomarker-Directed Therapies

View Therapies for Hairy Cell Leukemia

Of the biomarker-directed therapies for hairy cell leukemia, 0 are FDA-approved in at least one setting and 1 has NCCN guidelines in at least one setting [3].

Vemurafenib +

Clinical Trials

View Clinical Trials for Hairy Cell Leukemia

Significant Genes in Hairy Cell Leukemia

BRAF +

MYC +

Disease Details

Synonyms

HCL, Hairy Cell Leukemia (HCL), Leukemic Reticuloendotheliosis

Parent(s)

Mature B-Cell Neoplasm

Children

Splenic Manifestation of Hairy Cell Leukemia and Refractory Hairy Cell Leukemia

OncoTree Name

Hairy Cell Leukemia

OncoTree Code

HCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.

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