Overview

NCI Definition: Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003 [1]

Hematopoietic and lymphoid system neoplasms most frequently harbor alterations in TP53, TET2, DNMT3A, ASXL1, and JAK2 [2].

Most Commonly Altered Genes in Hematopoietic and Lymphoid System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, DNMT3A Mutation, and TET2 Mutation are the most common alterations in hematopoietic and lymphoid system neoplasm [2].

Top Alterations in Hematopoietic and Lymphoid System Neoplasm

Significant Genes in Hematopoietic and Lymphoid System Neoplasm

AKT1 +

AKT2 +

AKT3 +

CRKL +

EGFR +

ERBB2 +

IRS2 +

KIT +

MET +

MTOR +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RNF43 +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Parent(s)
Neoplasm
Children
Splenic Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Hematopoietic and Lymphoid Malignancy, Lymph Node Neoplasm, and Bone Marrow Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.