Overview

NCI Definition: A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. [1]

Hepatobiliary neoplasms most frequently harbor alterations in TP53, ARID1A, CDKN2A, KRAS, and IDH1 [2].

Most Commonly Altered Genes in Hepatobiliary Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in hepatobiliary neoplasm [2].

Top Alterations in Hepatobiliary Neoplasm

Significant Genes in Hepatobiliary Neoplasm

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Synonyms
Hepato-Biliary Tumor, Liver and Biliary System Neoplasm, Hepatic and Biliary Tumors, Hepatobiliary Tumors, Hepato-Biliary Neoplasm, Liver and Biliary Neoplasm, Hepatic, Biliary, and Gallbladder Neoplasms, Hepatobiliary Tumor, Hepatic and Biliary Neoplasms
Parent(s)
Digestive System Neoplasm
Children
Liver and Intrahepatic Bile Duct Neoplasm, Biliary Tract Neoplasm, and Malignant Hepatobiliary Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.