NCI Definition: An aggressive lymphoma with morphologic and molecular genetic features of both diffuse large B-cell lymphoma and Burkitt lymphoma. [1]

Significant Genes in High Grade B-Cell Lymphoma, Not Otherwise Specified


BCL2 +

BCL6 +

IRF4 +


Disease Details

High Grade B-Cell Lymphoma, NOS, HGBL, NOS, High-Grade B-Cell Lymphoma, Not Otherwise Specified, B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma, BCLU, High-Grade B-Cell Lymphoma, NOS
Diffuse Large B-Cell Lymphoma
OncoTree Name
High-Grade B-Cell Lymphoma, NOS
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.