Overview

NCI Definition: An aggressive lymphoma with morphologic and molecular genetic features of both diffuse large B-cell lymphoma and Burkitt lymphoma. [1]

High grade B-cell lymphoma, not otherwise specifieds most frequently harbor alterations in MYC, KMT2D, CCND3, BCR, and BCL2 [2].

Most Commonly Altered Genes in High Grade B-Cell Lymphoma, Not Otherwise Specified

KMT2D Mutation, CCND3 Mutation, BCR Mutation, BCL2 Mutation, and MYC Mutation are the most common alterations in high grade B-cell lymphoma, not otherwise specified [2].

Top Alterations in High Grade B-Cell Lymphoma, Not Otherwise Specified

Significant Genes in High Grade B-Cell Lymphoma, Not Otherwise Specified

AFF1 +

ALK +

BCL2 +

BCL6 +

CD274 +

ELL +

IRF4 +

KMT2A +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

Disease Details

Synonyms
High-Grade B-Cell Lymphoma, NOS, BCLU, High Grade B-Cell Lymphoma, NOS, High-Grade B-Cell Lymphoma, Not Otherwise Specified, HGBL, NOS, B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma
Parent(s)
Diffuse Large B-Cell Lymphoma
OncoTree Name
High-Grade B-Cell Lymphoma, NOS
OncoTree Code
HGBCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.