NCI Definition: A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes. [1]

Histiocytosiss most frequently harbor alterations in MAP2K1, TNFRSF14, SETD2, RPS6KB2, and PRDM1 [2].

Most Commonly Altered Genes in Histiocytosis

MAP2K1 Mutation, TNFRSF14 X184_splice, SETD2 R1625H, SETD2 Mutation, and RPS6KB2 V422I are the most common alterations in histiocytosis [2].

Top Alterations in Histiocytosis

Significant Genes in Histiocytosis


Disease Details

Histiocytic Infiltrate, Histiocytic Syndrome
Histiocytic and Dendritic Cell Neoplasm
OncoTree Name
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.