Overview

NCI Definition: A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes. [1]

Histiocytosiss most frequently harbor alterations in MAP2K1, TNFRSF14, SETD2, RPS6KB2, and PRDM1 [2].

Most Commonly Altered Genes in Histiocytosis

MAP2K1 Mutation, TNFRSF14 X184_splice, SETD2 R1625H, SETD2 Mutation, and RPS6KB2 V422I are the most common alterations in histiocytosis [2].

Top Alterations in Histiocytosis

Significant Genes in Histiocytosis

BRAF +

Disease Details

Synonyms
Histiocytic Infiltrate, Histiocytic Syndrome
Parent(s)
Histiocytic and Dendritic Cell Neoplasm
OncoTree Name
Histiocytosis
OncoTree Code
HIST

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.