Overview

NCI Definition: A squamous cell carcinoma arising from the hypopharynx. Signs and symptoms include dysphagia, hemoptysis, and the presence of a neck mass. [1]

Hypopharyngeal squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, and CCND1 [2].

Most Commonly Altered Genes in Hypopharyngeal Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and CCND1 Amplification are the most common alterations in hypopharyngeal squamous cell carcinoma [2].

Top Alterations in Hypopharyngeal Squamous Cell Carcinoma

Significant Genes in Hypopharyngeal Squamous Cell Carcinoma

CCND1 +

EGFR +

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Hypopharyngeal Epidermoid Carcinoma, Epidermoid Carcinoma of the Hypopharynx, Hypopharyngeal Throat Squamous Cell Cancer, Squamous Cell Carcinoma of the Hypopharynx, Squamous Cell Carcinoma of Hypopharynx, Epidermoid Carcinoma of Hypopharynx
Parent(s)
Hypopharyngeal Carcinoma
OncoTree Name
Hypopharynx Squamous Cell Carcinoma
OncoTree Code
HPHSC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.