Overview

NCI Definition: A fibrosarcoma that occurs in infants. It shares identical morphologic features with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that results in ETV6-NTRK3 gene fusion. It usually affects the superficial and deep soft tissues of the extremities. The prognosis is generally much more favorable than for adult fibrosarcoma, and it rarely metastasizes. [1]

Significant Genes in Infantile Fibrosarcoma

ETV6 +

NTRK1 +

NTRK2 +

NTRK3 +

Disease Details

Synonyms
Congenital Fibrosarcoma, Infantile fibrosarcoma (congenital fibrosarcoma)
Parent(s)
Childhood Fibrosarcoma
OncoTree Name
Infantile Fibrosarcoma
OncoTree Code
IFS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.