Overview

NCI Definition: An invasive transitional cell carcinoma that arises from the urinary bladder urothelium. [1]

Infiltrating bladder urothelial carcinomas most frequently harbor alterations in TP53, CDKN2A, KRAS, KMT2D, and KDM6A [2].

Most Commonly Altered Genes in Infiltrating Bladder Urothelial Carcinoma

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 7 Mutation, and TP53 Codon 245 Missense are the most common alterations in infiltrating bladder urothelial carcinoma [2].

Top Alterations in Infiltrating Bladder Urothelial Carcinoma

Disease Details

Synonyms
Invasive Bladder Urothelial Carcinoma, Infiltrating Transitional Cell Carcinoma of the Urinary Bladder, Invasive Transitional Cell Carcinoma of the Urinary Bladder, Invasive Bladder Transitional Cell Carcinoma
Parent(s)
Bladder Urothelial Carcinoma
Children
Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant, Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant, Superficial Bladder Urothelial Carcinoma, Infiltrating Bladder Urothelial Carcinoma, Nested Variant, Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant, Infiltrating Bladder Urothelial Carcinoma, Lipid-Rich Variant, Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant, Infiltrating Bladder Lymphoepithelioma-Like Carcinoma, Infiltrating Bladder Urothelial Carcinoma, Microcystic Variant, Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant, Infiltrating Bladder Urothelial Carcinoma with Squamous Differentiation, and Infiltrating Bladder Urothelial Carcinoma with Giant Cells

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.