Associated Genetic Biomarkers

Overview

NCI Definition: A multinodular intermediate fibroblastic neoplasm that arises from soft tissue or viscera, in children and young adults. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [1]

Inflammatory myofibroblastic tumors most frequently harbor alterations in ALK, ROS1, NOTCH2, TP53, and TET2 [2].

Most Commonly Altered Genes in Inflammatory Myofibroblastic Tumor

NOTCH2 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Mutation are the most common alterations in inflammatory myofibroblastic tumor [2].

Top Alterations in Inflammatory Myofibroblastic Tumor

Significant Genes in Inflammatory Myofibroblastic Tumor

ALK +

Disease Details

Synonyms
Inflammatory Pseudotumor, IMT, Inflammatory Myofibroblastic Neoplasm, Inflammatory Fibrosarcoma
Parent(s)
Fibroblastic Neoplasm
Children
Bladder Inflammatory Myofibroblastic Tumor, Lung Inflammatory Myofibroblastic Tumor, and Liver Inflammatory Myofibroblastic Tumor
OncoTree Name
Inflammatory Myofibroblastic Tumor
OncoTree Code
IMT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.