Associated Genetic Biomarkers


NCI Definition: A multinodular intermediate fibroblastic neoplasm that arises from soft tissue or viscera, in children and young adults. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [1]

Inflammatory myofibroblastic tumors most frequently harbor alterations in ALK, TFG, ROS1, RANBP2, and NOTCH1 [2].

Most Commonly Altered Genes in Inflammatory Myofibroblastic Tumor

ALK Fusion, TFG-ROS1 Fusion, ROS1 Fusion, RANBP2-ALK Fusion, and KRAS Mutation are the most common alterations in inflammatory myofibroblastic tumor [2].

Top Alterations in Inflammatory Myofibroblastic Tumor

Significant Genes in Inflammatory Myofibroblastic Tumor


Disease Details

Inflammatory Pseudotumor, PEDIATRIC Soft tissue inflammatory myofibroblastic tumor, Inflammatory Fibrosarcoma, Soft tissue inflammatory myofibroblastic tumor, Inflammatory Myofibroblastic Neoplasm, IMT
Fibroblastic Neoplasm
Lung Inflammatory Myofibroblastic Tumor, Bladder Inflammatory Myofibroblastic Tumor, and Liver Inflammatory Myofibroblastic Tumor
OncoTree Name
Inflammatory Myofibroblastic Tumor
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.