NCI Definition: A benign histiocytic tumor that occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck). It is sometimes associated with deep soft tissues nodules. 
There is 1 clinical trial for juvenile xanthogranuloma, of which 1 is open and 0 are completed or closed. Of the trial that contains juvenile xanthogranuloma as an inclusion criterion, 1 is phase 2 (1 open).
Cobimetinib is the most common intervention in juvenile xanthogranuloma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.