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Kidney Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms. [1]

Kidney carcinomas most frequently harbor alterations in VHL, PBRM1, SETD2, TP53, and BAP1 [2].

Most Commonly Altered Genes in Kidney Carcinoma

VHL Mutation, PBRM1fs, SETD2 Mutation, PBRM1 Mutation, and TP53 Mutation are the most common alterations in kidney carcinoma [2].

Top Alterations in Kidney Carcinoma

Clinical Trials

View Clinical Trials for Kidney Carcinoma

Significant Genes in Kidney Carcinoma

KRAS +

NTRK1 +

NTRK2 +

NTRK3 +

TP53 +

Disease Details

Synonyms
Kidney (including Renal Cell) Cancer, Kidney Cancer, Kidney cancer, NOS, Renal Carcinoma, Renal Cancer, Kidney carcinoma (NOS)
Parent(s)
Malignant Kidney Neoplasm
Children
Renal Cell Carcinoma, Kidney Small Cell Carcinoma, Kidney Medullary Carcinoma, and Renal Pelvis Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.