NCI Definition: A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx. [1]

Laryngeal squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and CCND1 [2].

Most Commonly Altered Genes in Laryngeal Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in laryngeal squamous cell carcinoma [2].

Top Alterations in Laryngeal Squamous Cell Carcinoma

Significant Genes in Laryngeal Squamous Cell Carcinoma




MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Larynx Epidermoid Carcinoma, Squamous Cell Carcinoma of the Larynx, Squamous Cell Carcinoma of Larynx, Epidermoid Carcinoma of Larynx, Larynx Squamous Cell Carcinoma, Epidermoid Carcinoma of the Larynx, Laryngeal Epidermoid Carcinoma
Laryngeal Carcinoma
Glottis Squamous Cell Carcinoma, Subglottic Squamous Cell Carcinoma, Laryngeal Verrucous Carcinoma, and Supraglottic Squamous Cell Carcinoma
OncoTree Name
Larynx Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.