NCI Definition: A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx. [1]

Laryngeal squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and CCND1 [2].

Most Commonly Altered Genes in Laryngeal Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and TP53 Exon 5 Mutation are the most common alterations in laryngeal squamous cell carcinoma [2].

Top Alterations in Laryngeal Squamous Cell Carcinoma

Significant Genes in Laryngeal Squamous Cell Carcinoma




Disease Details

Larynx Epidermoid Carcinoma, Squamous Cell Carcinoma of Larynx, Laryngeal Epidermoid Carcinoma, Larynx Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Larynx, Epidermoid Carcinoma of Larynx, Epidermoid Carcinoma of the Larynx
Laryngeal Carcinoma
Subglottic Squamous Cell Carcinoma, Supraglottic Squamous Cell Carcinoma, Laryngeal Verrucous Carcinoma, Glottis Squamous Cell Carcinoma, and Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant
OncoTree Name
Larynx Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.