Diseases /
Low Grade Ovarian Serous Adenocarcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A slow-growing serous adenocarcinoma that arises from the ovary. It usually originates from borderline neoplastic processes or adenofibromas. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures. [1]
Low grade ovarian serous adenocarcinomas most frequently harbor alterations in KRAS, BRAF, NRAS, CDKN2A, and KMT2D [2].
KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, KRAS G12V, and KRAS G12D are the most common alterations in low grade ovarian serous adenocarcinoma [2].
Clinical Trials
Significant Genes in Low Grade Ovarian Serous Adenocarcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.