Overview

NCI Definition: A slow-growing serous adenocarcinoma that arises from the ovary. It usually originates from borderline neoplastic processes or adenofibromas. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures. [1]

Low grade ovarian serous adenocarcinomas most frequently harbor alterations in KRAS, BRAF, NRAS, CDKN2A, and KMT2D [2].

Most Commonly Altered Genes in Low Grade Ovarian Serous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, KRAS G12V, and KRAS G12D are the most common alterations in low grade ovarian serous adenocarcinoma [2].

Top Alterations in Low Grade Ovarian Serous Adenocarcinoma

Significant Genes in Low Grade Ovarian Serous Adenocarcinoma

ATM +

ATR +

BARD1 +

BRCA1 +

BRCA2 +

BRIP1 +

CHEK1 +

CHEK2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

HRAS +

KRAS +

MCPH1 +

MRE11A +

NBN +

NRAS +

PALB2 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

SLX4 +

Disease Details

Synonyms
Low-Grade Ovarian Serous Adenocarcinoma
Parent(s)
Ovarian Serous Adenocarcinoma
OncoTree Name
Low-Grade Serous Ovarian Cancer
OncoTree Code
LGSOC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.