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Malignant Bile Duct Neoplasm

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Associated Genetic Biomarkers

Overview

Malignant bile duct neoplasms most frequently harbor alterations in TP53, KRAS, IDH1, ARID1A, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Bile Duct Neoplasm

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in malignant bile duct neoplasm [2].

Top Alterations in Malignant Bile Duct Neoplasm

Disease Details

Parent(s)
Malignant Hepatobiliary Neoplasm
Children
Bile Duct Sarcoma and Bile Duct Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.